B236 : ALK BY FISH (TC)

INFORMATION:

Alternate Name:

ALK BY FISH (TC)

Methodology:

FISH

Clinical Utility:

FISH for EML4-ALK is used to detect the presence of a fusion gene that can be targeted with an FDA approved tyrosine kinase inhibitor, crizotinib. All NSCLC adenocarcinoma patients can be tested for EML4-ALK but clinicopathologic features favor patients with little to no smoking history and those that are younger. CAP guidelines recommend EGFR and ALK testing in advanced stage adenocarcinoma regardless of sex, smoking history, and other clinical factors. Expert concensus opinion written in the CAP guidelines recommend EGFR and ALK testing for all stages of adenocarcinoma. ALK by FISH can also be used to confirm a diagnosis of Anaplastic Large Cell Lymphoma (ALCL) because it covers ALK1 status.

ORDERING:

Test Code:

B236-1

Turnaround Time:

3-5 DAYS

Preferred Specimen:

Formalin-fixed, Paraffin-embedded Tissue

Collection:

Container	Qty	Temp	Stability
Formalin-fixed, Paraffin-embedded Tissue	1	Room Temp	999 DAYS

Collection Instructions:

BLK: This comes in block form from client with surgical number imprint.

Storage Transport Instructions:

Custom Instruction: This comes in block from client with surgical number imprint.
Storage/Transport Instruction: Ship with cold pack during warm weather.

Specimen Comment:

Please include specimen collection date on requisition. Please write surgical number on block and on requisition. Provide fixation time on requisition as well **If sample submitted is a block there is no stability.**

Alternative Specimen:

Unstained Slide