TJ89 : OnkoSight Advanced 523 Gene NGS Panel

INFORMATION:

Alternate Name:

OnkoSight Advanced 523

Methodology:

Genotyping by Next Generation Sequencing

Clinical Utility:

523 gene panel which includes Tumor Mutation Burden (TMB) and microsatellite instability (MSI). List of 523 genes: ABL1 ABL2 ACVR1 ACVR1B AKT1 AKT2 AKT3 ALK ALOX12B ANKRD11 ANKRD26 APC AR ARAF ARFRP1 ARID1A ARID1B ARID2 ARID5B ASXL1 ASXL2 ATM ATR ATRX AURKA AURKB AXIN1 AXIN2 AXL B2M BAP1 BARD1 BBC3 BCL10 BCL2 BCL2L1 BCL2L11 BCL2L2 BCL6 BCOR BCORL1 BCR BIRC3 BLM BMPR1A BRAF BRCA1 BRCA2 BRD4 BRIP1 BTG1 BTK C11orf30 CALR CARD11 CASP8 CBFB CBL CCND1 CCND2 CCND3 CCNE1 CD274 CD276 CD74 CD79A CD79B CDC73 CDH1 CDK12 CDK4 CDK6 CDK8 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CENPA CHD2 CHD4 CHEK1 CHEK2 CIC CREBBP CRKL CRLF2 CSF1R CSF3R CSNK1A1 CTCF CTLA4 CTNNA1 CTNNB1 CUL3 CUX1 CXCR4 CYLD DAXX DCUN1D1 DDR2 DDX41 DHX15 DICER1 DIS3 DNAJB1 DNMT1 DNMT3A DNMT3B DOT1L E2F3 EED EGFL7 EGFR EIF1AX EIF4A2 EIF4E EML4 EP300 EPCAM EPHA3 EPHA5 EPHA7 EPHB1 ERBB2 ERBB3 ERBB4 ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERG ERRFI1 ESR1 ETS1 ETV1 ETV4 ETV5 ETV6 EWSR1 EZH2 FAM123B FAM175A FAM46C FANCA FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FAS FAT1 FBXW7 FGF1 FGF10 FGF14 FGF19 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FH FLCN FLI1 FLT1 FLT3 FLT4 FOXA1 FOXL2 FOXO1 FOXP1 FRS2 FUBP1 FYN GABRA6 GATA1 GATA2 GATA3 GATA4 GATA6 GEN1 GID4 GLI1 GNA11 GNA13 GNAQ GNAS GPR124 GPS2 GREM1 GRIN2A GRM3 GSK3B H3F3A H3F3B H3F3C HGF HIST1H1C HIST1H2BD HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HIST3H3 HLA-A HLA-B HLA-C HNF1A HNRNPK HOXB13 HRAS HSD3B1 HSP90AA1 ICOSLG ID3 IDH1 IDH2 IFNGR1 IGF1 IGF1R IGF2 IKBKE IKZF1 IL10 IL7R INHA INHBA INPP4A INPP4B INSR IRF2 IRF4 IRS1 IRS2 JAK1 JAK2 JAK3 JUN KAT6A KDM5A KDM5C KDM6A KDR KEAP1 KEL KIF5B KIT KLF4 KLHL6 KMT2B KMT2C KMT2D KRAS LAMP1 LATS1 LATS2 LMO1 LRP1B LYN LZTR1 MAGI2 MALT1 MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAP3K13 MAP3K14 MAP3K4 MAPK1 MAPK3 MAX MCL1 MDC1 MDM2 MDM4 MED12 MEF2B MEN1 MET MGA MITF MLH1 MLL MLLT3 MPL MRE11A MSH2 MSH3 MSH6 MST1 MST1R MTOR MUTYH MYB MYC MYCL1 MYCN MYD88 MYOD1 NAB2 NBN NCOA3 NCOR1 NEGR1 NF1 NF2 NFE2L2 NFKBIA NKX2-1 NKX3-1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NPM1 NRAS NRG1 NSD1 NTRK1 NTRK2 NTRK3 NUP93 NUTM1 PAK1 PA

ORDERING:

Test Code:

TJ89-2

Turnaround Time:

7-10 DAYS

Preferred Specimen:

Formalin-fixed, Paraffin-embedded Tissue

Collection:

Container	Qty	Temp	Stability
Formalin-fixed, Paraffin-embedded Tissue	1	Room Temp

Collection Instructions:

BLK: This comes in block form from client with surgical number imprint.

Storage Transport Instructions:

Storage/Transport Instruction: Specimen can be either RT or refrigerated
Ship with cold pack during warm weather.

Specimen Comment:

Extracted DNA is acceptable, providing that the isolation of nucleic acid occurs in a CLIA-certified laboratory or a laboratory meeting equivalent requirements as determined by CMS and/or the CAP.
This comes in block form from client with surgical imprint. 10-15 unstained slides at 5 microns (tumor content>10%) with H&E, Shavings (if tumor content>40%) with H&E.

Alternative Specimen:

Eppendorf tube, Unstained Slide