TP70 : OnkoRisk Hereditary Oncology Guideline Panel (Non-NYS)

INFORMATION:

Alternate Name:

OnkoRisk Guide (Non-NYS)

Methodology:

Genotyping by Next Generation Sequencing

Clinical Utility:

55 gene panel content for patients with or without cancer, only containing genes that are listed in national guidelines related to multiple hereditary cancer syndromes. This includes sequencing and deletion/duplication analysis. Non-NY only. Genes: APC ATM AXIN2 BAP1 BARD1 BMPR1A BRCA1 BRCA2 BRIP1 CDH1 CDK4 CDKN1B CDKN2A CHEK2 EPCAM FH FLCN HOXB13 GREM1 MAX MEN1 MET MLH1 MSH2 MSH3 MSH6 MUTYH NF1 NF2 PALB2 PMS2 POLD1 POLE PRKAR1A PTCH1 PTEN RAD51B RAD51C RAD51D RB1 RET SDHA SDHAF2 SDHB SDHC SDHD SMAD4 STK11 SUFU TMEM127 TP53 TSC1 TSC2 VHL WT1

ORDERING:

Test Code:

TP70-9

Turnaround Time:

14 DAYS

Preferred Specimen:

5-6 mL Peripheral Blood - Lavender Top

Collection:

Container	Qty	Temp	Stability
Peripheral Blood - Lavender Top	2	Room Temp

Collection Instructions:

LPB: Fill tube, invert gently 5-6 times, label with patient's name

Storage Transport Instructions:

Custom Instruction: Lavender: 2 tubes (5-6ml each) Label with the patient name, date of birth and/or ID. Ideal handling is to ship immediately at ambient temperature for overnight delivery.
Alternate sample type: DNA: Extract and submit DNA =50 ng/µL AND a volume of =100 µL in sterile container. 1.7 mL flip-cap microtube, 1.5 mL v-bottom screw cap tube, 0.5 mL v-bottom skirted tube or 2.0 mL v-bottom skirted tube is preferred. Ship DNA in sealed and protective packaging at ambient temperature, using a cool pack in hot weather. Labeling: Name of person or identifier, DNA concentration and volume MUST be provided on the specimen tube. Extracted DNA is acceptable, providing that the isolation of nucleic acid occurs in a CLIA-certified laboratory or a laboratory meeting equivalent requirements as determined by CMS and/or the CAP.
ORAcollect®•Dx device (catalog number OCD-100): Carefully read all instructions provided in the kit for the saliva sample collection instructions. Label with patient’s name, date of birth and/or ID.

Alternative Specimen:

Eppendorf tube, OraCollect Dx Swab