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Click hereWhile the majority of cancer is sporadic and occurs by chance, approximately 5-10% is hereditary and occurs because an individual was born with a harmful change in a gene that increased their risk to develop cancer. In general, it is estimated that approximately 5-10% of breast cancer, 5% of colorectal cancer, and up to 25% of ovarian cancer is due to a harmful change in a gene associated with hereditary cancer. Other types of cancer may also be hereditary.
Hereditary Cancers
Hereditary cancers are caused by pathogenic variants (harmful changes) in certain genes passed from one generation to the next. These pathogenic variants are usually inherited from a parent and can significantly increase the risk for one or more cancers.
Sporadic Cancers
Sporadic cancers are caused by a random event and are not passed from one generation to the next within a family. Sporadic cancers occur more frequently as we get older due to environmental and lifestyle exposures such as diet, weight, exercise, smoking, and alcohol use among others.
Individuals with a personal and/or family history of the following may be at risk for hereditary breast, ovarian, and/or endometrial cancer. Family history includes first, second, and third-degree blood relatives (including parents, siblings, children, aunts/uncles, cousins, and grandparents).
It is important to provide detailed information on the personal and family histories of cancer, including ages of diagnosis, pathology, and relationship between family members. This information can help determine if testing is appropriate and which test is medically necessary, as well as may impact insurance coverage.
These panels address a broad range of cancer susceptibility genes. Testing using these panels may be appropriate for patients/families with a wide spectrum of cancers.
Hereditary cancer testing is offered by BioReference through GenPath. GenPath is a leading expert in cancer diagnostics and offers a comprehensive test portfolio, including risk assessment for hereditary cancers.
A questionnaire which can help determine if individuals or other family members are candidates for genetic testing
MyGeneticsTree is a comprehensive, web-based tool for identifying patients who meet criteria for hereditary cancer genetic testing based on national guidelines.
MyGeneticsTree assesses patients’ personal and family medical histories, allows patients to securely share their risk assessment results, and assists healthcare providers with test ordering when patients meet criteria for hereditary cancer genetic testing. To learn more about MyGeneticsTree, contact your sales representative or send an email to support@mygeneticstree.com.
Our Hereditary Cancer Program advantages include access to genetic counseling support, patient-friendly billing policies, patient education materials and easy specimen collection options. GenPath also offers a helpful tool to assess your potential need for hereditary cancer testing called MyGeneticsTree. In as little as 15 minutes, you can learn whether hereditary cancer testing could benefit you. To learn more about MyGeneticsTree, click HERE
For additional information and resources, please click the link below to visit GenPath.
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