Back to Test DirectoryP264 : MSI by PCR if MSI-H Reflex to MLH1
INFORMATION:
Alternate Name:
Microsatellite Instability, High Rflx to MLH1 Hypermethylation
Methodology:
Immunohistochemistry
Clinical Utility:
Stage II colorectal cancer patients with microsatellite unstable (i.e., MSI-H) tumors typically do not respond favorably to chemotherapy. In addition, metastatic solid tumors that are MSI-H may derive benefit from pembrolizumab immunotherapy. MSI-H with reflex to MLH1 hypermethylation testing is also useful in the assessment of Lynch Syndrome. An alternative test is MMR by IHC.
ORDERING:
Test Code:
P264-5
Turnaround Time:
7 DAYS
Preferred Specimen:
Formalin-fixed, Paraffin-embedded Tissue
Collection:
| Container | Qty | Temp | Stability |
|---|---|---|---|
| Formalin-fixed, Paraffin-embedded Tissue | 1 | 999 DAYS |
Collection Instructions:
BLK: This comes in block form from client with surgical number imprint.
Storage Transport Instructions:
Custom Instruction: This comes in block or slide form from client with surgical number imprint.
Storage/Transport Instruction: Ship block with cold pack during warm weather.
Storage/Transport Instruction: Ship block with cold pack during warm weather.
Specimen Comment:
Please provide a copy of the pathology report.
Alternative Specimen:
Unstained Slide
Billing:
CPT Codes:
81301 x 1
CPT Code Disclaimer
CPT codes provided are for informational purposes only. Accuracy of CPT presented should be validated prior to consideration for billing.
CPT coding is the sole responsibility of the billing party. Please direct any questions regarding CPT coding to the payer being billed.
