TL95 : OnkoSight Advanced NGS Myeloid Panel

INFORMATION:

Alternate Name:

OSA NGS Myeloid

Methodology:

Genotyping by Next Generation Sequencing

Clinical Utility:

Tumor sequencing by NGS detecting mutations in 50 genes associated with myeloid malignancies. Mutations often have prognostic significance, may confer resistance to FDA approved therapies, or may qualify patients for late-stage clinical trials. Gene content: ABL1 ANKRD26 ASXL1 ATRX BCOR BCORL1 BRAF CALR CBL CCND2 CDKN2A CEBPA CSF3R CUX1 DDX41 DNMT3A ETNK1 ETV6 EZH2 FBXW7 FLT3 GATA2 HRAS IDH1 IDH2 JAK2 KDM6A KIT KMT2A KRAS MAP2K1 MPL MYD88 NF1 NPM1 NRAS PDGFRA PHF6 PTEN PTPN11 RUNX1 SETBP1 SF3B1 SRSF2 STAG2 TET2 TP53 U2AF1 WT1 ZRSR2

ORDERING:

Test Code:

TL95-4

Turnaround Time:

10 DAYS

Preferred Specimen:

2 mL Bone Marrow - Lavender Top

Collection:

Container	Qty	Temp	Stability
Bone Marrow - Lavender Top	1	Room Temp	30 DAYS

Collection Instructions:

BML: Place bone marrow into tube, label with patient's name

Storage Transport Instructions:

BML/BMG: Place bone marrow into tube, label with patient's name and send in provided kit.
LPB/GPB: Place peripheral blood into tube, label with patient's name and send in provided kit.
Alternative specimen: Extracted DNA is acceptable, providing that the isolation of nucleic acid occurs in a CLIA-certified laboratory or a laboratory meeting equivalent requirements as determined by CMS and/or the CAP.
Storage/Transport Instruction: Specimen can be either RT or refrigerated

Specimen Comment:

Decalcified specimens are not recommended for NGS testing.

Alternative Specimen:

Bone Marrow - Green Top, Peripheral Blood - Lavender Top, Peripheral Blood - Green Top, Eppendorf tube, Unstained Slide, Formalin-fixed, Paraffin-embedded Tissue