TM00 : OnkoSight Advanced NGS Comprehensive Myeloid Panel

INFORMATION:

Alternate Name:

OSAComprehensiveMyeloid

Methodology:

Genotyping by Next Generation Sequencing

Clinical Utility:

Tumor sequencing by NGS detecting mutations in 75 genes associated with myeloid malignancies. Mutations often have prognostic significance, may confer resistance to FDA approved therapies, or may qualify patients for late-stage clinical trials. Gene content: ABL1 ANKRD26 ASXL1 ATRX BCOR BCORL1 BRAF BTK CALR CBL CBLB CBLC CCND2 CDC25C CDKN2A CEBPA CSF3R CUX1 CXCR4 DCK DDX41 DHX15 DNMT3A ETNK1 ETV6 EZH2 FBXW7 FLT3 GATA1 GATA2 GNAS HRAS IDH1 IDH2 IKZF1 JAK2 JAK3 KDM6A KIT KMT2A KRAS LUC7L2 MAP2K1 MPL MYC MYD88 NF1 NOTCH1 NPM1 NRAS PDGFRA PHF6 PPM1D PTEN PTPN11 RAD21 RBBP6 RPS14 RUNX1 SETBP1 SF3B1 SH2B3 SLC29A1 SMC1A SMC3 SRSF2 STAG2 STAT3 TET2 TP53 U2AF1 U2AF2 WT1 XPO1 ZRSR2

ORDERING:

Test Code:

TM00-2

Turnaround Time:

10 DAYS

Preferred Specimen:

2 mL Bone Marrow - Lavender Top

Collection:

Container	Qty	Temp	Stability
Bone Marrow - Lavender Top	1	Room Temp	30 DAYS

Collection Instructions:

BML: Place bone marrow into tube, label with patient's name

Storage Transport Instructions:

BML/BMG: Place bone marrow into tube, label with patient's name and send in provided kit.
LPB/GPB: Place peripheral blood into tube, label with patient's name and send in provided kit.
Alternative specimen: Extracted DNA is acceptable, providing that the isolation of nucleic acid occurs in a CLIA-certified laboratory or a laboratory meeting equivalent requirements as determined by CMS and/or the CAP.
Storage/Transport Instruction: Specimen can be either RT or refrigerated

Specimen Comment:

Decalcified specimens are not recommended for NGS testing.

Alternative Specimen:

Peripheral Blood - Green Top, Bone Marrow - Green Top, Peripheral Blood - Lavender Top, Eppendorf tube, Unstained Slide, Formalin-fixed, Paraffin-embedded Tissue